Junjun Liu

Junjun Liu

Ph.D., Professor, Department of Biological Sciences, College of Science

Email

Phone number

909.869.2505

Office location

Building 4, 1-414

Office hours

T | 4 PM - 5 PM

Selected Publications

  1. Yu, W., Liu, J., Morrice, N.A., and Wettenhall, R.E.H. Isolation and characterization of a structural homologue of human PRK2 from rat liver. Distinguishing substrate and lipid activator specificities. J Biol Chem. 1997 Apr 11;272(15):10030-4.
  2. Liu, J., Lewellyn, A.L., Chen, L.G., and Maller, J.L. The polo box is required for multiple functions of Plx1 in mitosis. J Biol Chem. 2004 May 14;279(20):21367-73.
  3. Liu, J. and Maller, J.L. Xenopus Polo-like kinase Plx1: a multifunctional mitotic kinase. Oncogene. 2005 Jan 10;24(2):238-47.
  4. Eyers, P.A., Liu, J., Hayashi, N.R., Lewellyn, A.L., Gautier, J., and Maller, J.L. Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase. J Biol Chem. 2005 Jul 1;280(26):24339-46.
  5. Liu, J., and Maller, J.L. Calcium elevation at fertilization coordinates phosphorylation of XErp1/Emi2 by Plx1 and CaMK II to release metaphase arrest by cytostatic factor. Curr Biol. 2005 Aug 23;15(16):1458-68. (This paper was featured in Nature. 2005 Oct 13;437(7061):963-5.)
  6. Grimison, B., Liu, J., Lewellyn, A.L., and Maller, J.L. Metaphase arrest by cyclin E/Cdk2 requires the spindle-checkpoint kinase Mps1. Curr Biol., 2006 Oct 10;16(19):1968-73.
  7. Liu, J., Grimison B., Maller, J.L. The APC/C inhibitor Emi2 is essential for meiotic but not mitotic cell cycles. J Biol Chem, 2006 Nov 17;281(46):34736-41.
  8. Liu, J., Grimison, B., Maller, J.L. New insights into metaphase arrest by cytostatic factor: from establishment to release. Oncogene, 2007 Feb 26;26(9):1286-9
  9. Gajewski, J.E., Bird, M.J., Crowhurst, M.O., Lio, D., Liu, J., Wettenhall, R.E.H., Zhu, H., and Cheng, H-C. Expression, Generation and Purification of Unphosphorylated and Phospho-Ser-380/Thr-382/Thr-383 Form of Recombinant PTEN phosphatase. Protein Expression and Purification, 2007 May 10.
  10. Jingyan Fu, Minglei Bian, Junjun Liu, Qing Jiang and Chuanmao Zhang. A Single Amino Acid Transition Converts Aurora-A into Aurora-B-like Kinase in Terms of Partner Specificity and Cellular Function. Proc Natl Acad Sci U S A. 2009 Apr 28;106 (17):6939-44
  11. Xiaoyan Zhang, Qiang Chen, Jia Feng, Junjun Liu, Qing Jiang and Chuanmao Zhang. Sequential Phosphorylation of Nedd1 by Cdk1 and Plk1 is required for γTuRC targeting to centrosome. J Cell Sci. 2009 Jul 1;122(Pt 13):2240-51.
  12. Gang Wang,Qiang Chen, Xiaoyan Zhang, Boyan Zhang, Xiaolong Zhuo, Junjun Liu, Qing Jiang and Chuanmao Zhang. PCM1 Recruits Plk1 to Pericentriolar Matrix to Promote Primary Cilia Disassembly before Mitotic Entry. J Cell Sci. 2013 Mar 15;126(Pt 6):1355-65.
  13. Liu. Regulating Greatwall for Mitosis. Cell Cycle. 2015 Jan 15:0.
  14. Zhuo X, Guo X, Zhang X, Jing G, Wang Y, Chen Q, Jiang Q, Liu J*, Zhang C* (*co-corresponding authors). Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. J Cell Biol. 2015 Aug 31;210(5):727-35.
  15. Ji Q, Lee J, Lin YH, Jing G, Tsai LJ, Chen A, Hetrick L, Jocoy D, Liu J. Atrazine and malathion shorten the maturation process of Xenopus laevis oocytes and have an adverse effect on early embryo development. Toxicol In Vitro. 2016 Apr;32:63-9.
  16. Liu J*, Zhang C* (*co-corresponding authors). The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation. Cell Mol Life Sci. 2017 Feb 10. 
  17. Huabo Chen, Xiaowei Xu, Guopeng Wang, Boyan Zhang, Gang Wang, Guangwei Xin, Junjun Liu, Qing Jiang, Hongyin Zhang, and Chuanmao Zhang. CDK4 is degraded by APC/C in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells. J. Biol. Chem. 2017 Jun 16;292(24):10131-10141.
  18. Jade Lolarga, Ebtesam Nafie, Brandon Lam, Jonathan Guo, Elnaz Abdollahzadeh, Sandy Rodriguez, Carlotta Glackin, Junjun Liu. Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1. PLOS ONE, 2021 Feb 24;16(2)