Jason Ear

Jason Ear

Assistant Professor , Biological Sciences, College of Science

Email

Phone number

(909) 869-4086

Office location

Building 4, 3-758

Office hours

W | 9 AM - 11:30 AM

Publications

 

  1. Ear J, Abd El-Hafeez AA, Roy S, Ngo T, Rajapakse N, Choi J, Khandelwal S, Ghassemian M, McCaffrey L, Kufareva I, Sahoo D, Ghosh P. A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding. J Biol Chem. 2021 Jan-Jun;296:100493. doi: 10.1016/j.jbc.2021.100493. Epub 2021 Mar 3. PubMed PMID: 33675748; PubMed Central PMCID: PMC8042451.

 

  1. Sharma A, Lee J, Fonseca AG, Moshensky A, Kothari T, Sayed IM, Ibeawuchi SR, Pranadinata RF, Ear J, Sahoo D, Crotty-Alexander LE, Ghosh P, Das S. E-cigarettes compromise the gut barrier and trigger inflammation. iScience. 2021 Feb 19;24(2):102035. doi: 10.1016/j.isci.2021.102035. eCollection 2021 Feb 19. PubMed PMID: 33537654; PubMed Central PMCID: PMC7841355.

 

  1. Ear J, Saklecha A, Rajapakse N, Choi J, Ghassemian M, Kufareva I, Ghosh P. Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. iScience. 2020 Feb 21;23(2):100859. doi: 10.1016/j.isci.2020.100859. Epub 2020 Jan 22. PubMed PMID: 32058970; PubMed Central PMCID: PMC7005484.

 

  1. Marivin A, Maziarz M, Zhao J, DiGiacomo V, Olmos Calvo I, Mann EA, Ear J, Blanco-Canosa JB, Ross EM, Ghosh P, Garcia-Marcos M. DAPLE protein inhibits nucleotide exchange on Gαsand Gαq via the same motif that activates Gαi. J Biol Chem. 2020 Feb 21;295(8):2270-2284. doi: 10.1074/jbc.RA119.011648. Epub 2020 Jan 16. PubMed PMID: 31949046; PubMed Central PMCID: PMC7039542.

 

  1. Ear J*, Dunkel Y*, Mittal Y, Lim BBC, Liu L, Holda MK, Nitsche U, Barbazán J, Goel A, Janssen KP, Aznar N, Ghosh P. Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors. Sci Rep. 2019 Aug 20;9(1):12124. doi: 10.1038/s41598-019-48420-w. PubMed PMID: 31431650; PubMed Central PMCID: PMC6702192. *equal contribution

 

  1. Dunkel Y, Reid AL, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M, Ghosh P. Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma. Sci Rep. 2018 Dec 21;8(1):18036. doi: 10.1038/s41598-018-36173-x. PubMed PMID: 30575751; PubMed Central PMCID: PMC6303298.

 

  1. Aznar N*, Ear J*, Dunkel Y, Sun N, Satterfield K, He F, Kalogriopoulos NA, Lopez-Sanchez I, Ghassemian M, Sahoo D, Kufareva I, Ghosh P. Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple. Sci Signal. 2018 Feb 27;11(519). doi: 10.1126/scisignal.aao4220. PubMed PMID: 29487190; PubMed Central PMCID: PMC5862031. *equal contribution

 

  1. Aznar N, Sun N, Dunkel Y, Ear J, Buschman MD, Ghosh P. A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. Mol Biol Cell. 2017 Dec 1;28(25):3709-3723. doi: 10.1091/mbc.E17-06-0405. Epub 2017 Oct 11. PubMed PMID: 29021338; PubMed Central PMCID: PMC5706997.

 

  1. Ear J, Lin S. RNA methylation regulates hematopoietic stem and progenitor cell development. J Genet Genomics. 2017 Oct 20;44(10):473-474. doi: 10.1016/j.jgg.2017.09.004. Epub 2017 Sep 21. PubMed PMID: 29037987.

 

  1. Ghosh P, Aznar N, Swanson L, Lo IC, Lopez-Sanchez I, Ear J, Rohena C, Kalogriopoulos N, Joosen L, Dunkel Y, Sun N, Nguyen P, Bhandari D. Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin. Curr Protoc Chem Biol. 2016 Dec 7;8(4):265-298. doi: 10.1002/cpch.13. PubMed PMID: 27925669; PubMed Central PMCID: PMC5154557.

 

  1. Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. GIV/Girdin activates Gαi and inhibits Gαs via the same motif. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12. PubMed PMID: 27621449; PubMed Central PMCID: PMC5047194.

 

  1. Ear J, Hsueh J, Nguyen M, Zhang Q, Sung V, Chopra R, Sakamoto KM, Lin S. A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure. J Genet Genomics. 2016 May 20;43(5):307-18. doi: 10.1016/j.jgg.2016.03.007. Epub 2016 Apr 2. PubMed PMID: 27216296.

 

  1. Ear J, Huang H, Wilson T, Tehrani Z, Lindgren A, Sung V, Laadem A, Daniel TO, Chopra R, Lin S. RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1. Blood. 2015 Aug 13;126(7):880-90. doi: 10.1182/blood-2015-01-622522. Epub 2015 Jun 24. PubMed PMID: 26109203.

 

  1. Lin C*, Ear J*, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014 Nov 5;25(22):3654-71. doi: 10.1091/mbc.E14-05-0978. Epub 2014 Sep 3. PubMed PMID: 25187647; PubMed Central PMCID: PMC4230624. *equal contribution

 

  1. Zhang Y, Ear J, Yang Z, Morimoto K, Zhang B, Lin S. Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19. Cell Death Dis. 2014 Jul 24;5:e1352. doi: 10.1038/cddis.2014.318. PubMed PMID: 25058426; PubMed Central PMCID: PMC4123107.

 

  1. Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Mädler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small. 2013 May 27;9(9-10):1776-85. doi: 10.1002/smll.201202128. Epub 2012 Nov 23. PubMed PMID: 23180726; PubMed Central PMCID: PMC4034474.

 

  1. Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU. Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure. 2011 Dec 7;19(12):1826-36. doi: 10.1016/j.str.2011.09.018. PubMed PMID: 22153505; PubMed Central PMCID: PMC3240820.

 

  1. Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P. Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal. 2011 Sep 27;4(192):ra64. doi: 10.1126/scisignal.2002049. PubMed PMID: 21954290; PubMed Central PMCID: PMC4226136.

 

  1. Stafford RL, Ear J, Knight MJ, Bowie JU. The molecular basis of the Caskin1 and Mint1 interaction with CASK. J Mol Biol. 2011 Sep 9;412(1):3-13. doi: 10.1016/j.jmb.2011.07.005. Epub 2011 Jul 12. PubMed PMID: 21763699; PubMed Central PMCID: PMC3158819.

 

  1. Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell. 2011 Mar 1;22(5):673-86. doi: 10.1091/mbc.E10-08-0738. Epub 2011 Jan 5. PubMed PMID: 21209316; PubMed Central PMCID: PMC3046063.

 

  1. Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011 Feb;25(2):590-9. doi: 10.1096/fj.10-167304. Epub 2010 Oct 25. PubMed PMID: 20974669; PubMed Central PMCID: PMC3023389.

 

  1. Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010 Jul 1;21(13):2338-54. doi: 10.1091/mbc.e10-01-0028. Epub 2010 May 12. PubMed PMID: 20462955; PubMed Central PMCID: PMC2893996.

 

  1. Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010 Apr 23;285(17):12765-77. doi: 10.1074/jbc.M109.045161. Epub 2010 Feb 15. PubMed PMID: 20157114; PubMed Central PMCID: PMC2857069.